Recompensation in patients with autoimmune hepatitis-related decompensated cirrhosis following immunosuppressive therapy.

ABSTRACT:

Background & aims

In this study, we aimed to evaluate the incidence, predictors, and prognostic significance of recompensation in autoimmune hepatitis (AIH)-related decompensated cirrhosis following immunosuppressive therapy (IST).

Methods

We retrospectively analyzed patients with AIH at first decompensation. Recompensation, defined using modified Baveno VII criteria, required clinical resolution (≥12 months without ascites, variceal bleeding, or hepatic encephalopathy, with liver function restored to Child-Pugh A) along with aetiological suppression (complete biochemical response under IST). Predictors of recompensation were identified using multivariate regression, and survival outcomes were compared among compensated, recompensated, and non-recompensated groups.

Result

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12355535 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature