The impact of pregabalin and gabapentin on essential tremor: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Essential tremor (ET) is a common neurological disorder characterized by involuntary rhythmic oscillations. Emerging evidence suggests that gabapentinoids, including gabapentin and pregabalin, may be effective in managing ET. This study aimed to assess the efficacy of gabapentinoids in treating ET by analyzing data from randomized controlled trials (RCTs).

Methods

A systematic search was conducted across various databases to identify relevant RCTs utilizing gabapentin or pregabalin. Tremor severity was evaluated using the total tremor score (TTS) and accelerometry.

Results

In a between-group meta-analysis of seven RCTs (N = 235), gabapentinoids did not significantly outperform placebo in reducing TTS or its subscales. Accelerometry data suggested a

SUBMITTER: Pourbala H 

PROVIDER: S-EPMC12355546 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature