Oxidative modulation of Piezo1 channels.

ABSTRACT: Emerging evidence suggests that mechanosensitive Piezo1 channels play a role in the pathomechanism of various disorders. However, the mechanisms by which accumulating pathologies regulate Piezo1 activation remain unclear. Oxidative stress, a common feature of neurodegenerative diseases, is associated with generation of reactive oxygen species (ROS). While the dependence of Piezo1 channels on temperature, pH, and voltage has been well studied, the redox regulation of these highly mechanosensitive channels remains unknown. We investigated whether oxidative stress modulates the calcium permeability of Piezo1 channels using red blood cells (RBCs) and HEK293T cells transduced with Piezo1 as model systems. Additionally, using the selective H₂O₂ sensor HyPer7, we examined wh

SUBMITTER: Novosolova N 

PROVIDER: S-EPMC12355560 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature