Immune-compatible designs of semiconducting polymers for bioelectronics with suppressed foreign-body response.

ABSTRACT: One of the greatest obstacles to achieving implantable electronics with long-term functionality and minimized inflammatory reactions is the immune-mediated foreign-body response (FBR). Recently, semiconducting polymers with mixed electron-ion conductivity have been demonstrated as promising candidates to achieve direct electrical interfacing on bio-tissues. However, there is limited understanding of their immune compatibility in vivo, and strategies for minimizing the FBR through molecular design remain underexplored. Here we introduce a set of molecular design strategies for enhancing the immune compatibility of semiconducting polymers. Specifically, we show that selenophene, when incorporated in the backbone, can mitigate the FBR by suppressing macrophage activation. In addition, side-ch

SUBMITTER: Li N 

PROVIDER: S-EPMC12355568 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature