Colonic inflammation modulates the intestinal circadian landscape.

ABSTRACT: Inflammatory bowel disease (IBD) is a chronic inflammatory condition that carries significant morbidity. The circadian (24h) clock regulates many aspects of immunity, and circadian disruption is implicated in inflammatory disease. We examined the impact of acute dextran sulfate sodium-induced colitis on the intestinal circadian landscape and investigated the consequences of intestinal epithelial cell (IEC) clock disruption on immune function in health and under inflammatory stress. Within the inflamed colon, we observed attenuated IEC clock function. Furthermore, de novo oscillations in numbers of colonic regulatory T cells emerged, associated with diurnal variation in proliferation and activation markers. IEC-specific deletion of core clock gene Bmal1 drove alterations in th

SUBMITTER: Butler TD 

PROVIDER: S-EPMC12355569 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature