Evaluating the risk of digestive system cancer in autoimmune disease patients: a systematic review and meta-analysis focusing on bias assessment.

ABSTRACT:

Background

There is emerging evidence that certain autoimmune diseases can modulate the risk for digestive system cancer. However, limitations of non-experimental studies may lead to diverging results. Thus, the aim was to evaluate the available evidence and provide bias-minimized estimates for the associations between celiac disease (CD), systemic lupus erythematosus (SLE), multiple sclerosis (MS), and type 1 diabetes (T1D) and different digestive system cancers.

Methods

Systematic review (PROSPERO: CRD42024553216) was conducted according to PRISMA guidelines. Scientific publications were searched in PubMed, Web of Science, Embase, and Cochrane Library from inception up to May 2, 2025, with no restrictions on publication date. ROBINS-E tool was used for examining the study-

SUBMITTER: Reizner J 

PROVIDER: S-EPMC12355593 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature