Enhanced Antifungal Efficacy through Controlled Delivery of Amphotericin B Loaded in Polyetheramine-Epoxide Nanogels.

ABSTRACT: Polymeric nanomaterials have emerged as promising carriers for drug delivery systems, offering improved therapeutic efficacy and reduced toxicity. In this study, we present an environmentally friendly and scalable approach for engineering nanogels as an innovative delivery platform for Amphotericin B (AmB), which is a potent antifungal agent. The nanogel system, named NanoT, was synthesized via an amine-epoxide reaction, enabling effective encapsulation and sustained release of AmB. Comprehensive physicochemical characterization was conducted using transmission electron microscopy (TEM), dynamic light scattering (DLS), ζ potential analysis, proton nuclear magnetic resonance (1H-NMR), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), and synchrotron-based ultra-

SUBMITTER: Reinaldi JS 

PROVIDER: S-EPMC12355616 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature