The role of interface geometry and appendages on the mesoscale mechanics of the skin.

ABSTRACT: The skin is the largest organ in the human body and serves various functions, including mechanical protection and mechanosensation. Yet, even though skin's biomechanics are attributed to two main layers-epidermis and dermis-computational models have often treated this tissue as a thin homogeneous material or, when considering multiple layers, have ignored the most prominent heterogeneities of skin seen at the mesoscale. Here, we create finite element models of representative volume elements (RVEs) of skin, including the three-dimensional variation of the interface between the epidermis and dermis as well as considering the presence of hair follicles. The sinusoidal interface, which approximates the anatomical features known as Rete ridges, does not affect the homogenized mechanical respons

SUBMITTER: Moreno-Flores O 

PROVIDER: S-EPMC12355621 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature