Functional Self-Immolative Hydrogels with Dendritic Cross-Linkers for Controlled Drug Delivery.

ABSTRACT: In the biomedical field, the design of materials with controlled degradation is highly desired. Herein, we present a family of dendritic hydrogels accomplished through copper-assisted azide-alkyne cycloaddition click reaction between dendritic cross-linkers and complementary linear polymers. As cross-linkers, an innovative family of bifunctional carbosilane dendrimers was designed for this purpose, bearing multiple alkyne groups available for network formation as well as pendant hydroxyl groups for postfunctionalization. Additionally, different azide-pendant polymers were employed, including difunctional poly-(ethylene glycol) with cleavable and noncleavable nature, as well as poly-(ethyl glyoxylate) with and without self-immolative behavior. The rational design of the dendritic hydrogels,

SUBMITTER: Munoz-Sanchez S 

PROVIDER: S-EPMC12355646 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature