Genome-wide association analysis provides insights into the genomics and extracellular expression of <i>Staphylococcus aureus</i> proteases.

ABSTRACT: Extracellular proteases are a class of Staphylococcus aureus virulence factors that thwart the immune system, promote nutrient acquisition, and shape the activity of virulence determinants. S. aureus displays considerable phenotypic and genotypic variation within clinically important lineages, giving rise to diverse infection types. Therefore, understanding how protease expression influences pathogenicity requires consideration of the underlying genes and their regulation in natural populations. In this study we determined the protease activity of 134 USA300 S. aureus isolates from clinical infections and asymptomatic carriage. In high-throughput casein hydrolysis assays, bloodstream infection isolates had significantly lower protease activity than carriage isolates. T

SUBMITTER: Li S 

PROVIDER: S-EPMC12355673 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature