A Combined Experimental and Modeling Workflow to Tune Surface Properties of Organic Materials via Cocrystallization.

ABSTRACT: Cocrystallization is a specific crystal engineering strategy widely used to enhance the dissolution rate or bioavailability of active pharmaceutical ingredients. In this work, we demonstrate how cocrystallization can also be used to tune surface properties of crystalline particles, such as facet-specific surface chemistry, polarity, and wettability. As a model system, we have isolated a cocrystal of quercetin (Que) with imidazole (Im). Que is widely recognized for its potential antioxidative and antibacterial properties and other potentially beneficial therapeutic effects. Surface chemistry is a property that can affect ease of manufacturability (e.g., flowability) and storage stability (e.g., tendency to agglomerate) for particulate materials; here, we used cocrystallization to modify thi

SUBMITTER: Parisi E 

PROVIDER: S-EPMC12355690 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature