Overexpression of NK4 gene in TU212 affects migratory activity in laryngeal squamous cell carcinoma.

ABSTRACT:

Background

Abnormal activation of the hepatocyte growth factor (HGF) and c-mesenchymal-epithelial transition factor (c-Met) signaling pathway is associated with tumor occurrence and development. Serum HGF concentrations are significantly higher in patients with advanced and poorly differentiated laryngeal squamous cell carcinoma than those with early and highly differentiated disease. NK4, a splice variant of HGF, can competitively bind to c-Met and acts as a specific antagonist of HGF. Although preliminary research has been conducted on the tumor-suppressing function of the NK4 gene, its specific mechanism of action in laryngeal cancer remains unclear.

Methods

Stable laryngeal squamous cell carcinoma cell lines expressing NK4 were developed using a lent

SUBMITTER: Huo Y 

PROVIDER: S-EPMC12355930 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature