MASH Resolution Index: development and validation of a non-invasive score to detect histological resolution of MASH.

ABSTRACT:

Background

Dynamic changes in non-invasive tests, such as changes in alanine aminotransferase (ALT) and MRI proton-density-fat-fraction (MRI-PDFF), may help to detect metabolic dysfunction-associated steatohepatitis (MASH) resolution, but a combination of non-invasive tests may be more accurate than either alone. We developed a novel non-invasive score, the MASH Resolution Index, to detect the histological resolution of MASH.

Methods

This study included a derivation cohort of 95 well-characterised adult participants (67% female) with biopsy-confirmed MASH who underwent contemporaneous laboratory testing, MRI-PDFF and liver biopsy at two time points. The primary objective was to develop a non-invasive score to detect MASH resolution with no worsening of fibrosis. The most pre

SUBMITTER: Loomba R 

PROVIDER: S-EPMC12355936 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature