Advanced Proteomics Approaches Hold Potential for the Risk Assessment of Metabolism-Disrupting Chemicals as Omics-Based NAM: A Case Study Using the Phthalate Substitute DINCH.

ABSTRACT: The concept of metabolic disruption through exposure to chemicals has expanded our understanding of how environmental pollution can contribute to metabolic dysregulation and, ultimately, diseases like obesity. New strategies for assessing the risks posed by chemicals are needed, and omics technologies, including proteomics, have proven to be powerful tools for investigating the molecular mechanisms of these metabolism-disrupting chemicals (MDCs). A potential MDC is the plasticizer DINCH─an alternative to legacy phthalates like DEHP, whose primary metabolite MINCH has been linked to the induction of adipogenesis and lipid accumulation. Here, global proteomics was complemented with insights into protein thermal stability and the profiles of post-translational modification (PTM) acetylation a

SUBMITTER: Aldehoff AS 

PROVIDER: S-EPMC12355959 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature