Maternal immune activation alters infant attentional processing in a nonhuman primate model.

ABSTRACT: Maternal infection during pregnancy has been linked to the emergence of neurodevelopmental disorders. Preclinical animal models of maternal immune activation (MIA) have provided critical mechanistic links between maternal cytokines and alterations in offspring brain and behavioral development. While most preclinical work on MIA used rodent models, nonhuman primate (NHP) models have strong translational potential due to their greater similarity with humans. Previous NHP MIA models have replicated rodent findings of atypical offspring behavior emerging as animals mature, but few studied MIA-induced alterations in infancy. Here, we present a unique contribution on early milestones of attention in males using a rhesus monkey NHP MIA model. During an assessment of imitation conducted at 1 week-

SUBMITTER: Hubbard JA 

PROVIDER: S-EPMC12356000 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature