C-reactive protein is associated with pain-type somatic symptoms independent of mental health symptoms in adolescents: Evidence from the ALSPAC study.

ABSTRACT: Depression and anxiety disorders frequently first present during adolescence, and both conditions are often comorbid with the experience of pain-type somatic symptoms. Moreover, increased concentrations of blood-derived inflammatory markers, such as C-reactive protein (CRP), have been observed in both depression and anxiety. Altered neuroimmune activation may impact on pain signalling pathways in the nervous system, potentially playing a role in the relationship between mental health and pain-type somatic symptoms. This study conducted cross-sectional secondary data analyses of the Avon Longitudinal Study of Parents and Children (ALSPAC) dataset, using a sample of 2877 participants at age 18. Baron and Kenny's (1986) mediation framework was used to explore whether CRP acts as a mediator be

SUBMITTER: Cooney-Quane J 

PROVIDER: S-EPMC12356028 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature