Regulation of hedonic feeding rhythms by circadian clocks in leptin-receptive neurons.

ABSTRACT:

Objective

The circadian clock anticipates daily repetitive events to adapt physiological processes. In mammals, the circadian system consists of a master clock in the suprachiasmatic nucleus (SCN), which synchronizes subordinate tissue clocks, including extra-SCN central nervous system (CNS) clocks involved in functions such as sleep and appetite regulation. Appetite is controlled by both homeostatic and non-homeostatic (hedonic) circuits. Homeostatic appetite addresses energy needs, while hedonic feeding targets cravings for palatable, calorie-dense foods. The adipokine leptin is a major appetite regulator, interacting with the circadian clock. Although leptin's role in satiation through its action in the mediobasal hypothalamus (MBH) is well established, its involvement in the ci

SUBMITTER: Osorio-Mendoza J 

PROVIDER: S-EPMC12356030 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature