Ligand modification for the tuning of activity and selectivity in the chemoselective transfer hydrogenation of α,β-unsaturated carbonyls using EtOH as a hydrogen source.

ABSTRACT: The selective reduction of α,β-unsaturated ketones, either at the olefinic or the carbonyl site, offers attractive synthetic opportunities. While carbonyl reduction is well established, selective olefin reduction is less common, particularly when using environmentally friendly ethanol as a hydrogen source. Recently, we reported a coordinatively unsaturated ruthenium complex containing an N,N'-bidentate coordinating pyridinium amidate (PYA) ligand as an efficient catalyst for ethanol-based transfer hydrogenation of α,β-unsaturated ketones; however, there was over-reduction and thus loss of selectivity in reactions over an extended period of time. Capitalizing on the facile synthetic modulation of PYA ligands, we herein report on a series of operationally unsaturated two-legged

SUBMITTER: Beaufils A 

PROVIDER: S-EPMC12356170 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature