Increased Extra-Axial Cerebrospinal Fluid Volume in Children with Angelman Syndrome: Links to Sleep Problems and Seizures.

ABSTRACT:

Background

Previous studies demonstrated that children with autism have enlarged volumes of extra-axial cerebrospinal fluid (EA-CSF) and increased ratio of EA-CSF to brain volume, indicating that EA-CSF is disproportionally increased beyond macrocephaly often observed in autism. It is unknown whether EA-CSF is disproportionally enlarged in Angelman syndrome (AS), which shares phenotypic features with autism (sleep problems, seizures) but is characterized by microcephaly. This study examined EA-CSF and total cerebral volume (TCV) in AS children compared to neurotypical (NT) controls to test whether EA-CSF is disproportionally enlarged and is associated with sleep problems and seizures.

Methods

MRI scans were acquired in n=29 AS (M[SD]=6.95±2.83 years) and n=27 NT children (M[

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12356226 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature