Microstructural alterations of the trigeminal ganglion in chronic ocular surface pain patients: A diffusion MRI study.

ABSTRACT: Noxious stimuli to the ocular surface are encoded by sensory axons of trigeminal ganglion (TG) neurons and conveyed through the ophthalmic branch of the trigeminal nerve (CN V1). We hypothesized that chronic ocular surface pain (COSP) may be associated with microstructural alterations of the trigeminal nerve structures. Our objective was to demonstrate the feasibility of using diffusion tractography to identify and analyze diffusion properties to assess TG microstructure in individuals with and without COSP. Forty COSP patients (27 males and 13 females; mean age: 56.2 ± 11.9 yrs; range: 34-77 yrs) and 17 controls without pain (15 males and 2 females; mean age: 55.4 ± 8.9 yrs, range: 37-66 yrs) were included in the study. Using 3T diffusion MRI (dMRI), we performed tractography to reconstru

SUBMITTER: Ortug A 

PROVIDER: S-EPMC12356230 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature