Deep representation learning of electrocardiogram reveals biological insights in cardiac phenotypes and cardiovascular diseases.

ABSTRACT: Conventional approaches to analyzing electrocardiograms (ECG) in discrete parameters (such as the PR interval) ignored the high dimensionality of data omitted subtle but relevant information. We applied a variational auto-encoder to learn the underlying distributions of the ECG of 41,927 UK Biobank participants, generating 32-dimensional representation (latent factors). The latent factors showed correlations to conventional ECG parameters and strong associations to cardiac phenotypes estimated from magnetic resonance imaging. We found definitive associations of the latent factors to conduction, rhythm, and structural disorders (all p < 4.51 × 10^-308) and additionally value in mortality prediction. Genome wide association study (GWAS) of the latent factors, revealed 170 ge

SUBMITTER: Yeung MW 

PROVIDER: S-EPMC12356350 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature