Biomaterial-mediated Cell Atlas: an insight from single-cell and spatial transcriptomics.

ABSTRACT: Biomaterials serve as bridges between synthetic structures and biological systems, facilitating interactions with bodily tissues and regulating cellular responses. However, the intricate mechanisms governing cell-material interactions within the body are not fully understood. To address these challenges, single-cell transcriptomics and spatial technologies have emerged as promising tools. This review introduces the concept of the 'Biomaterial-mediated Cell Atlas' and summarizes its recent advances in biomaterials research. Building upon the framework of the Human Cell Atlas, it can extend its scope to include biomaterial-mediated cellular responses. The principles and workflows of single-cell and spatial transcriptomics are then presented, emphasizing their potential to reveal cellular div

SUBMITTER: Yang X 

PROVIDER: S-EPMC12356410 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature