Caffeic acid phenethyl ester promotes palatal wound healing and enhances wound-associated macrophage CD68 expression.

ABSTRACT:

Objectives

Palatal wounds may result in open lesions, which can lead to extended inflammation, discomfort, wound contraction, scar tissue development, interference with phonation or mastication, and disruption of maxillofacial growth. Flavonoids are known to possess the ability to diminish macrophage pro-inflammatory activity and to facilitate macrophage-mediated resolution of inflammation, thereby accelerating the healing process. Caffeic acid phenethyl ester (CAPE), the principal bioactive constituent of propolis, belongs to this family, and is known to diminish inflammatory cell count, accelerate wound contraction, and promote re-epithelialisation by decreasing lipid peroxidation and the production of reactive oxygen species. This study assesses the impact of CAPE on macrophage

SUBMITTER: Suningdyastiningrum AO 

PROVIDER: S-EPMC12356463 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature