Touch-Enabled Reversible Microfluidic Ultradense Chips for Convenient, High-Throughput Electrochemical Assays.

ABSTRACT: Here, we present a new approach to reversibly bond microfluidic polydimethylsiloxane (PDMS) channels on low-cost, reproducible, scalable, compact, and ultradense multisensor SU-8-coated chips toward high-throughput electrochemical assays. Based on putting the outlets at the bottom of PDMS, the method only needs manually attaching this substrate on a flat surface, thus offering simplicity, throughput, and reversibility. While a plasma-mediated approach failed to provide leakage-free bonding, the reversibly bonded devices presented a high adhesion strength, withstanding a pressure of at least 5.1 MPa. Because the approach is high-pressure tolerant and reversible, it can deliver both long-term analyses and ease of sampling in-channel material for posterior manipulation/characterization and ev

SUBMITTER: da Silva PHN 

PROVIDER: S-EPMC12356537 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature