Advances in the Detection and Management of Vulnerable Coronary Plaques.

ABSTRACT: Efforts to enhance risk stratification in patients with coronary artery disease have driven the pursuit of early detection of rupture-prone plaques-before destabilization and the onset of life-threatening thrombosis-giving rise to the concept of the vulnerable plaque (VP). Invasive diagnostic modalities closely mirror histology and provide instrumental information on VP hallmarks and their prognostic significance. However, limited positive predictive value and invasive nature restrict their use for systematic screening. Noninvasive techniques offer broader application potential, but their specificity and resolution remain inferior to those of invasive techniques. A deeper understanding of the complex interplay between traditional ischemic risk factors, anatomic settings, rheological effect

SUBMITTER: Spagnolo M 

PROVIDER: S-EPMC12356569 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature