Effect of Hydroxychloroquine in a Mouse Model of Abortion Caused by <i>Brucella abortus</i> Infection.

ABSTRACT: Hydroxychloroquine (HCQ) has showed beneficial effects on pregnancy outcomes in systemic erythaematosus lupus (SLE) by its anti-inflammatory and immunomodulatory properties. However, the role of HCQ in preventing abortion caused by infectious diseases remains unknown. In this study, we choose B. abortus-induced abortion of pregnant mice as a model to investigate the effect of HCQ in preventing abortion. HCQ decreases the pH value of endosomal Brucella-containing vacuole (eBCV), B. abortus type IV secretion system (T4SS) expression in trophoblasts and Brucella intracellular growth and cell death. Moreover, administration of HCQ decreases inflammation triggered by dead trophoblasts in a T4SS-independent manner. Mechanistically, this suppressed inflammatory respons

SUBMITTER: Liu H 

PROVIDER: S-EPMC12356681 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature