MRI-based human brain atlases of R1, R2, proton density, and myelin volume fraction using synthetic quantitative imaging at 1.5 T.

ABSTRACT: Quantitative MRI (qMRI) enables objective, reproducible measurement of tissue-specific MR properties, offering improved diagnostic accuracy and deeper insight into disease mechanisms compared to conventional MRI. Parameters such as proton density (PD), relaxation rates (R1, R2), and myelin volume fraction (MVF) provide valuable information on tissue composition, water content, and myelination. Reference qMRI atlases based on these parameters are essential for identifying deviations in individuals and supporting clinical decision-making. While several reference atlases exist, none offer comprehensive, multi-parametric data derived from a single acquisition dataset. In this study, we constructed four synthetic 3D reference brain atlases (isotropic resolution 1.5 mm) of PD, R1, R2, and MVF us

SUBMITTER: Sbaihat H 

PROVIDER: S-EPMC12356715 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature