Thyme-synthesized silver nanoparticles mitigate immunosuppression, oxidative damage, and histopathological alterations induced by multidrug-resistant Enterococcus faecalis in Oreochromis niloticus: in vitro and in vivo assays.

ABSTRACT: The escalating prevalence of antibiotic resistance poses a significant challenge to controlling aquatic diseases, underscoring the need for innovative antimicrobial approaches. Therefore, the current study aimed to investigate the effects of thyme-synthesized silver nanoparticles (thyme-AgNPs) on modulating the immunosuppressive, oxidative stress, and histopathological changes induced by multidrug-resistant Enterococcus faecalis (MDR E. faecalis) infection in Oreochromis niloticus (Nile tilapia). The antibiotic susceptibility profiling of the isolated E. faecalis (PQ084785) revealed resistance to multiple antibiotic classes. The in vitro bactericidal efficacy of thyme-AgNPs was confirmed, with minimum bactericidal concentrations (MBC) and minimum inhibitory concentrations (MIC) of 62.5 µg/

SUBMITTER: Abdel-Moneam DA 

PROVIDER: S-EPMC12356727 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature