Low Intensity Pulsed Ultrasounds Modulate Adipose Stem Cells Differentiation.

ABSTRACT: LIPUS, low intensity pulsed ultrasounds, are considered a safe and non-invasive tool that have been used extensively in medicine for chronic diseases. We evaluated the effects produced by LIPUS on the physiological behaviour of mouse and human adipose stem cells (ASCs) as well as on adipose tissue explants. LIPUS stimulation for one minute did not affect mouse or human ASC proliferation or apoptosis, with no evident changes in morphology or cell growth. Further, RNA-seq analysis revealed more than 200 genes differentially expressed after ultrasound stimulation of mouse and human ASCs. Among them, the changes in gene expression mainly belong to the canonical pathways of stemness, energy metabolism or chemokine signalling. On the other hand, the migration ability of mouse and human ASCs was

SUBMITTER: Fernandez-Marcelo T 

PROVIDER: S-EPMC12356745 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature