Polygenic scores for dizygotic twinning: insights into the genetic architecture of female fertility.

ABSTRACT:

Purpose

Natural dizygotic twinning (DZT) results from hyper-ovulation and is an indicator of female fertility. However, some traits linked to DZ twinning are also associated with infertility. We examined the relationship between DZT and female (in)fertility using recent GWAS findings.

Methods

We investigated the genetic architecture of DZT and compared polygenic scores (PGS) for DZT between mothers of naturally conceived DZ twin pregnancies and mothers who required fertility treatments (MAR) in the Netherlands Twin Register (NTR) and the Norwegian Mother, Father, and Child Cohort Study (MoBa). We also calculated genetic correlations between DZT and seven fertility related traits.

Results

DZT has a low polygenicity, with only 0.20% of SNPs estimated to have a nonzero e

SUBMITTER: Hubers N 

PROVIDER: S-EPMC12356781 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature