Development of a preclinical X-rays minibeam Monte Carlo treatment planning system.

ABSTRACT: Minibeam Radiation Therapy (MBRT) delivers spatially fractionated beams, generating alternating high-dose peaks and low-dose valleys, with potential benefits in tumor control and normal tissue sparing. This study presents the development of a Monte Carlo (MC) Treatment Planning System (TPS) for preclinical MBRT, preceded by an investigation of various collimator configurations and a comparison of MC simulations with experimental data. Multiple simulations were conducted to evaluate different combinations of attenuator materials (lead, tungsten) and spacer materials (PMMA, air), as well as various slit widths (0.5-1 mm). Among the tested configurations, tungsten and PMMA emerged as the most suitable materials. As expected, the peak-to-valley dose ratio (PVDR) decreased with depth, while the

SUBMITTER: Pizzardi S 

PROVIDER: S-EPMC12356841 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature