Growth kinetics of high-grade serous ovarian cancer: implications for early detection.

ABSTRACT:

Background

High-grade serous ovarian cancer (HGSOC) is the most lethal gynaecological cancer with patients routinely diagnosed at advanced stages. Evidence from randomized controlled trials indicates that annual screening may not reduce cancer-related deaths. We aim to characterise the growth kinetics of HGSOC to understand why early detection failed and under what conditions it might prove fruitful.

Methods

We analysed data from 597 HGSOC patients and identified 34 cases with serial CT scans. We calculated the growth rates of lesions in the ovaries/pelvis and the omentum and estimated the time to metastasis using a Gompertz model. Finally, we simulated ultrasound and CA125 based screening in a virtual population of patients.

Results

Growing lesions in the ovaries and

SUBMITTER: Narayanan B 

PROVIDER: S-EPMC12356848 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature