Association between methylation quantitative trait loci and colorectal cancer risk, survival and cancer recurrence.

ABSTRACT:

Background

Epigenetic changes contribute to colorectal cancer (CRC) pathogenesis. We investigated whether methylation quantitative trait loci (mQTLs) are associated with CRC risk, survival and recurrence.

Methods

Using a well-characterised Scottish case-control study (6821 CRC cases, 14,692 controls), we derived 118,982 mQTLs based on the Genetics of DNA Methylation Consortium (GoDMC). Association analysis between mQTLs and CRC risk, survival and recurrence was performed using logistic regression or Cox models respectively. Additionally, colocalisation analysis was performed.

Results

19 mQTLs within 10 distinct genomic regions were associated with CRC risk. Two novel regions were mapped to MDGA2 (p value =  3.0×10-6 ) and STARD3 (p value =  5.6×10-6 ). Four regions ma

SUBMITTER: Mesa-Eguiagaray I 

PROVIDER: S-EPMC12356881 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature