The aggregate index of systemic inflammation is positively correlated with the risk of all-cause mortality in sepsis-associated acute kidney injury.

ABSTRACT: Sepsis is a major health problem worldwide, and sepsis-associated acute kidney injury (SA-AKI) patients usually experience severe conditions, high mortality, and long length of stay. The predictive value of aggregate index of systemic inflammation (AISI) in the prognosis of several diseases has been documented. This study intends to investigate the association between AISI and mortality in SA-AKI. Data of patients with SA-AKI first admitted to the intensive care unit in 2008-2019 were acquired from the Medical Information Mart for Intensive Care IV (MIMIC-IV). The impact of AISI on 30-/90-/180-d and 1-year mortality in SA-AKI was investigated by Cox proportional hazard regression models, Kaplan-Meier analyses, and restricted cubic spline (RCS) analyses. Moreover, subgroup analyses, stratif

SUBMITTER: Liu R 

PROVIDER: S-EPMC12356892 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature