Longitudinal changes in striatocortical connectivity in first-episode psychosis associated with the emergence of treatment resistance.

ABSTRACT: Treatment resistance affects up to one in four individuals with psychosis in the first few years of illness. However, there is limited information about the brain changes associated with treatment resistance, restricting our ability to develop effective prognostic biomarkers or new treatments. Using resting-state functional MRI, we examined striatocortical connectivity in 87 patients who presented a non-affective first-episode of psychosis and 118 healthy controls, with follow-up imaging on more than half of the participants in the next 6 years, totaling 361 images. Crucially, we identified 30 patients who presented treatment-resistant psychosis in this follow-up period. Thus, we examined baseline (at first episode) and longitudinal striatocortical differences within psychosis subgroups (t

SUBMITTER: Tepper A 

PROVIDER: S-EPMC12356903 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature