CCR7⁺ dendritic cells expressing both IL-23A and IL-12B potentially contribute to psoriasis relapse.

ABSTRACT: Interleukin (IL)-23 is the master pathogenic cytokine in psoriasis and neutralization of IL-23 alleviates psoriasis. Psoriasis relapses after the withdrawal of anti-IL-23 antibodies, and the persistence of IL-23-producing cells potentially contributes to such recurrence, but the cellular source of IL-23 is unclear. Here we show that IL4I1⁺CD200⁺CCR7⁺ dendritic cells (CCR7⁺ DC) are the main producer of IL-23 by concomitantly expressing the IL-23A and IL-12B subunits in human psoriatic skin. Deletion of CCR7⁺ DC completely abrogates IL-23 production in a mouse model of psoriasis, while enforced expression of IL-23a in CCR7⁺ DC elicits not only αβT cell-driven psoriasis-like skin disease, but also arthritis. CCR7⁺ DC

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12356920 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature