Predictive capabilities of polygenic scores in an East-Asian population-based cohort: the Singapore Chinese health study.

ABSTRACT: Polygenic scores (PGS) are derived primarily from European population studies. It is unclear how these perform in risk predictions among East-Asians. We generated 2173 PGSs from 519 traits and assessed their associations with 58 baseline phenotypes in the Singapore Chinese Health Study, a prospective cohort of 23,622 Chinese adults residing in Singapore. PGS performances were evaluated through explained variance (r²) and area under the receiver operating characteristic curve (AUC) in linear and logistic regression models, respectively. Traits with higher heritability exhibited stronger PGS associations, while behavioural traits, like sleep duration, showed weaker associations. Height and type 2 diabetes (T2D) exhibited largest SNP-based heritability with the largest increments in explained

SUBMITTER: Chang X 

PROVIDER: S-EPMC12356951 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature