Haplo-stem cell transplant post liver transplantation to cure sickle cell disease with related liver dysfunction: a case series.

ABSTRACT:

Background

Sickle cell disease (SCD) is debilitating, with age-dependent complications such as stroke and liver disease, leading to significant morbidity and early mortality in young adults. Hematopoietic stem cell transplantation (HCT) is curative treatment for SCD, but transplantation-related risks often deter its use, especially in patients with severe comorbidities. A subset of severe SCD patients with significant end-organ dysfunction may benefit from a combined approach of HCT and solid organ transplantation (SOT).

Methods

To the best of our knowledge, this report presents, for the first time, the utilization of dual orthotopic liver transplantation and haploidentical HCT (haplo-HCT) for severe SCD with advanced liver cirrhosis. Employing nonmyeloablative conditioning

SUBMITTER: Alahmari AD 

PROVIDER: S-EPMC12356966 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature