Mechanism and regulatory strategy study on promoting vascularized bone regeneration via intracellular zinc ion transport.

ABSTRACT: Bone regeneration is a major clinical challenge. The main obstacles to bone injury repair are local blood flow disorders and hypoxic microenvironments. Mesenchymal stem cell (MSC) therapy has notable advantages in promoting bone-tissue regeneration. In this study, we established a mouse model of skull bone injury treated with bone marrow mesenchymal stem cells (BMSCs). We found that local BMSC transplantation stimulated vascularized bone regeneration and matrix metalloproteinase (MMP)10 was the major regulatory protein. Local hypoxic microenvironment-induced mitochondrial permeability increased, resulting in cytoplasmic Zn²⁺ accumulation, which is a key factor in activating the JAK1/STAT1/MMP-10 pathway. The cytoplasmic Zn²⁺ enrichment caused ZRT/IRT-like protein 6 (Z

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12357053 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature