Inhibition of eIF5A hypusination enhances antioxidant defense to prevent kidney Ischemia/Reperfusion injury.

ABSTRACT: Ischemia/reperfusion (I/R) refers to the interruption or reduction of blood flow followed by its sudden restoration, resulting in significant oxidative stress, particularly in the kidneys, which are highly oxygen-dependent and metabolically active. During I/R, excessive production of reactive oxygen species (ROS) is triggered by mitochondrial dysfunction and activation of oxidases. Cellular antioxidant defences which attempt to neutralise ROS can become overwhelmed, resulting in oxidative stress that damages macromolecules and ultimately impairs cell function and survival. In kidney transplantation, ROS-induced I/R injury contributes to delayed graft function and chronic graft loss. In this context, inhibition of eIF5A hypusination using the deoxyhypusine synthase inhibitor GC7 protects ki

SUBMITTER: Cougnon M 

PROVIDER: S-EPMC12357257 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature