Isoquercitrin mitigates intestinal ischemia-reperfusion injury by regulating intestinal flora and inhibiting NLRP3 inflammasome activation.

ABSTRACT: Intestinal ischemia-reperfusion (II/R) injury, frequently observed in clinical emergencies such as trauma, infection, and transplantation, leads to severe epithelial necrosis, loss of villi, and alarmingly high mortality rates (50 %-90 %), yet current pharmaceutical treatments largely prove ineffective. This study employs network pharmacology alongside in vivo and in vitro experiments to explore the potential of isoquercitrin, a flavonoid abundant in various dietary sources and known for its anti-inflammatory and antioxidant properties, in mitigating intestinal II/R injury. We found that isoquercitrin significantly reinforced the integrity of the intestinal barrier and markedly alleviated damage associated with II/R injury. Additionally, it enhanced the intestinal microbiota structure by p

SUBMITTER: Xu H 

PROVIDER: S-EPMC12357270 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature