Adults with celiac disease exhibit overexpression of endogenous retroviruses, TRIM28, and SETDB1 despite gluten-free diet.

ABSTRACT: Celiac disease (CeD) is a disorder due to abnormal immune response to gluten protein in individuals with predisposing genotypes. Its origin is not fully understood. Human endogenous retroviruses (HERVs) derive from ancestral infections of germinal cells and represent 8 % of the human DNA. They are mostly inactive, but some can be activated. Their aberrant expressions are associated with inflammatory and immune-mediated diseases. HERV transcription is modulated by TRIM28 and SETDB1, which are also directly implicated in epigenetic processes and modulation of the immune response. We reported HERV overexpressions in CeD children at diagnosis. In the current prospective study, using a PCR real-time Taqman amplification assay, we explored the transcription levels of HERV-H-pol, -HERV-K-pol, and

SUBMITTER: Tovo PA 

PROVIDER: S-EPMC12357293 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature