Pathway-Specific Polygenic Scores for Predicting Clinical Lithium Treatment Response in Patients With Bipolar Disorder.

ABSTRACT:

Background

Polygenic scores (PGSs) hold the potential to identify patients who respond favorably to specific psychiatric treatments. However, their biological interpretation remains unclear. In this study, we developed pathway-specific PGSs (PS_PGSs) for lithium response and assessed their association with clinical lithium response in patients with bipolar disorder.

Methods

Using sets of genes involved in pathways affected by lithium, we developed 9 PS_PGSs and evaluated their associations with lithium response in the International Consortium on Lithium Genetics (ConLi⁺Gen) (N = 2367), with validation in combined PsyCourse (Pathomechanisms and Signatures in the Longitudinal Course of Psychosis) (N = 105) and BipoLife (N = 1

SUBMITTER: Sharew NT 

PROVIDER: S-EPMC12357302 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature