Neuronal endolysosomal alterations induced by Apolipoprotein E4 emerge over time in primary neurons.

ABSTRACT: Apolipoprotein E4 (ApoE4), the major genetic risk factor for Alzheimer's disease (AD), is vital for understanding cellular processes involved in AD pathogenesis. Evidence implicates endosomes as a central player in AD, where endosomal enlargement in neurons is among the earliest changes in AD. This enlargement was reported to be enhanced in APOE4 carriers. Cells internalize ApoE into endosomes for lipid delivery, and previous studies indicate that ApoE4 influences endosomes. However, the effect of ApoE4 on endosome function seems different depending on cell type, and our understanding of how ApoE4 influences endosomes in mature neurons, the cell type degenerating in AD, remains limited. We aimed to increase understanding of the impact ApoE4 has on endosomal dynamics in primary neurons and

SUBMITTER: Nyberg E 

PROVIDER: S-EPMC12357307 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature