Anti-MDA5 antibody IgG1 subtype is associated with rapidly progressive interstitial lung disease in anti-MDA5-positive dermatomyositis.

ABSTRACT:

Background

Rapidly progressive interstitial lung disease (RP-ILD) is a severe, often fatal complication in patients with anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis (MDA5⁺ DM). Early prediction of RP-ILD still remains challenging. We aimed to explore the link between anti-MDA5 IgG subtypes and ILD prognosis in individuals with MDA5⁺ DM.

Methods

In a retrospective study involving 71 MDA5⁺ DM-ILD patients, initial serum titers of anti-MDA5 IgG subtypes were measured using indirect immunofluorescence. We then analyzed the associations between these IgG subclasses and the development of RP-ILD.

Result

Of the 71 patients, 30% developed RP-ILD. RP-ILD patients had a shorter disease course and a higher mo

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12357345 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature