Neolignans isolated from industrial hemp (Cannabis sativa L.) roots have cytotoxic effects on cancer cells.

ABSTRACT:

Background

The 2018 Farm Bill states that cultivars of Cannabis sativa L. (industrial hemp) are legal for industrial use if total tetrahydrocannabinol (THC) concentrations are less than 0.30%. Due to this legislation, hemp cultivars with low total THC have found a wide range of uses, from animal feed to paper production. Although cannabinoids are the most widely studied compounds in hemp, hemp produces numerous other compound classes as well, and these phytochemicals may have uses in the functional food and pharmaceutical industry.

Methods

Initial liquid chromatography profiling of hemp root samples revealed a group of uncharacterized peaks, and these peaks were tentatively identified as neolignans by Oribitrap ID-X high resolution mass spectrometer. To further elucidate the

SUBMITTER: Brownstein KJ 

PROVIDER: S-EPMC12357354 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature