Exploring the gut microbiota associated with peripheral nerve invasion in colorectal cancer patients and constructing predictive models.

ABSTRACT:

Objective

This study aims to explore the differences in composition, abundance, and biological functions of the gut microbiota between colorectal cancer (CRC) patients with peripheral nerve invasion (PNI) and those without peripheral nerve invasion (NPNI). Additionally, we tried to construct a machine-learning predictive model incorporating the identified microbiota characteristics to explore the impact of gut microbiota on CRC-PNI progression and to search for new non-invasive microbiological indicators for CRC-PNI. Finally, we successfully developed a predictive model to predict PNI in CRC patients through leveraging microbial biomarkers. This innovative approach is expected to offer a novel strategy for the early detection of CRC metastasis, thereby facilitating more informed de

SUBMITTER: Chen C 

PROVIDER: S-EPMC12357365 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature