M6A-modified circZNF548 regulates exosomal miR-7108-3p to activate CD3⁺CD8⁺ T cells and suppress NSCLC growth by JMY.

ABSTRACT:

Background

Communication between cancer cells and tumor microenvironment (TME) plays a complicated role in cancer malignancy. Circular RNAs (circRNAs), known for their stability and conservation, contribute to TME remodeling in various cancers. This study aims to investigate the role of N6-methyladenosine (m6A)-modified circZNF548 in the proliferation and migration of non-small cell lung cancer (NSCLC) within the TME.

Results

circZNF548 expression is lower in NSCLC tissues than that in adjacent normal controls, and the higher circZNF548 levels correlate with the improved patient survival. circZNF548 overexpression suppresses NSCLC cell proliferation and migration, whereas siRNA-mediated downregulation promotes proliferation and migration. METTL14 overexpression decreases cir

SUBMITTER: Zhao YL 

PROVIDER: S-EPMC12357428 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature