MicroRNA-4516 in extracellular vesicles-derived mesenchymal stem cells suppressed integrin αV-mediated lung fibrosis.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is characterized by the recruitment of lung fibroblasts to sites within the lung interstitium, along with the differentiation of myofibroblasts induced by transforming growth factor (TGF)-β1, a mediator of fibrosis, which, in turn, leads to accelerated contractile lung fibrotic processes with excessive extracellular matrix (ECM) deposition. Extracellular vesicles (EVs) are small particles released by cells that contain physiologically active substances, including messenger RNAs, microRNAs (miRNAs), and proteins. Although EVs derived from mesenchymal stem cells (MSCs) are expected to be a promising drug for various intractable diseases, including IPF, the underlying mechanisms remain elusive. In this study, we aimed to elucidate the mec

SUBMITTER: Sumiyoshi I 

PROVIDER: S-EPMC12357429 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature