DPP4 inhibition curbs systemic inflammation.

ABSTRACT:

Background

Systemic inflammation is a critical clinical condition regularly observed in the context of surgery-induced trauma or infection. Systemic inflammation induces an ubiquitous activation of the vasculature and vascular dysfunction related to organ damage and adverse outcomes. The dipeptidyl peptidase-4 (DPP4) modulates the receptor preferences and activity of a multitude of humoral substrates mediating the systemic inflammatory response. We here determined whether DPP4 inhibition is a means to beneficially modulate systemic inflammatory responses affecting vascular and organ integrity.

Methods

In cardiac surgery patients medicated with DPP4 inhibitors, we used a systems biology approach for in-depth characterization of the perioperative immune response and assessment

SUBMITTER: Hellenthal KEM 

PROVIDER: S-EPMC12357438 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature